Skin is the largest organ to repel attacks from external agents and functioning as both a physical and immunological barrier. Its protective layer essentially composed of proteins and lipids such as Keratins, Fillagrins, Involucrins are essential component of the cornified envelope. Collagen and Elastin are found in the deep layers of skin (extracellular matrix) and are among others principally engaged in skin mechanical properties. As a rule of thumb, UV induced Oxidative stress as well as post translational protein modifications (PTMs), could affect skin elasticity and its mechanical integrity. Self-renewing and lipids production impairment, barrier functions loss, dark spots appearance (1) are common signs of aging skin.
With MS-Phylogene, you can characterize the PTMs and understand the effects on skin mechanical integrity and properties.
High-resolution nano LC-MS/MS quantitative proteomics and CORAVALID™ data processing: The efficient tool for discovery
High-resolution MRM nano LC-MS/MS quantitative proteomics: The efficient tool for follow-up
(1)Bio-derived hydroxystearic acid ameliorates skin age spots and conspicuous pores
https://doi.org/10.1111/ics.12529
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